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Article

Uncovering Intermolecular Interactions Driving the Liquid-Liquid Phase Separation of the TDP-43 Low-Complexity Domain via Atomistic Dimerization Simulations.

Journal of chemical information and modeling - 14 Oct 2024

Tang Huayuan, Sun Yunxiang, Wang Lei, Ke Pu Chun, Ding Feng

Abstract excerpt

Liquid-liquid phase separation (LLPS) of transactive response DNA-binding protein of 43 kDa (TDP-43), which exerts multiple functions in the splicing, trafficking, and stabilization of RNA, mediates the formation of membraneless condensates with crucial physiological roles, while its aberrant LLPS is linked to multiple neurodegenerative diseases. However, due to the heterogeneous and dynamic nature of LLPS, major...

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PMID: 39342654
DOI: 10.1021/acs.jcim.4c00943
PMCID: PMC11590498

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