Article

Protein Language Model Identifies Disordered, Conserved Motifs Implicated in Phase Separation

2024-12-13

Abstract excerpt

Intrinsically disordered regions (IDRs) play a critical role in phase separation and are essential for the formation of membraneless organelles (MLOs). Mutations within IDRs can disrupt their multivalent interaction networks, altering phase behavior and contributing to various diseases. Therefore, examining the evolutionary constraints of IDRs provides valuable insights into the relationship between protein sequen...

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Literature Corpus work: 6553192e-e2f0-59b7-9ff3-71d6957fc0a4
DOI: 10.1101/2024.12.12.628175

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