Article

Multi-Domain Interplay Controls Full-Length TDP-43 Phase Separation and Condensate Dynamics

2026-06-04

Abstract excerpt

TDP-43 (TAR DNA-binding protein 43) is a 414-amino acid protein with a structured N-terminal domain (NTD), two RNA recognition motifs (RRM1 and RRM2), and a long disordered C-terminal low complexity domain (LCD). TDP-43 forms phase-separated condensates as part of its physiological function in RNA processing. However, aberrant TDP-43 condensation, changes in condensate material properties, and subsequent aggregati...

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Literature Corpus work: 020ab288-5ce0-56d0-b1a0-699abcdfb945
DOI: 10.64898/2026.06.03.729912

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