Article
TDP-43 α-helical structure tunes liquid-liquid phase separation and function.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2020
Conicella Alexander E, Dignon Gregory L, Zerze Gül H, Schmidt Hermann Broder, D'Ordine Alexandra M, Kim Young C, Rohatgi Rajat, Ayala Yuna M, Mittal Jeetain, Fawzi Nicolas L
Abstract excerpt
Liquid-liquid phase separation (LLPS) is involved in the formation of membraneless organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is present in several MLOs, undergoes LLPS, and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). While some ALS-associated mutations in TDP-43 disrupt self-interaction and function, here we show that designed single mutations...
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