Article

Constrained Instruments and their Application to Mendelian Randomization with Pleiotropy

2017-11-30

Abstract excerpt

In Mendelian randomization (MR), genetic variants are used to construct instrumental variables, which enable inference about the causal relationship between a phenotype of interest and a response or disease outcome. However, standard MR inference requires several assumptions, including the assumption that the genetic variants only influence the response through the phenotype of interest. Pleiotropy occurs when a g...

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Literature Corpus work: 9976d2f7-864a-52db-9e5e-2a93878526eb
DOI: 10.1101/227454

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