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Article

Testing and correcting for weak and pleiotropic instruments in two-sample multivariable Mendelian randomization.

Statistics in medicine - 10 Nov 2021

Sanderson Eleanor, Spiller Wes, Bowden Jack

Abstract excerpt

Multivariable Mendelian randomization (MVMR) is a form of instrumental variable analysis which estimates the direct effect of multiple exposures on an outcome using genetic variants as instruments. Mendelian randomization and MVMR are frequently conducted using two-sample summary data where the association of the genetic variants with the exposures and outcome are obtained from separate samples. If the genetic...

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PMID: 34338327
DOI: 10.1002/sim.9133
PMCID: PMC9479726

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