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Article

An optimized instrument variable selection approach to improve causality estimation in association studies.

Scientific reports - 1 Oct 2024

Sharma Jyoti, Jangale Vaishnavi, Swain Asish Kumar, Yadav Pankaj

Abstract excerpt

Mendelian randomization (MR) is an emerging tool for inferring causality in genetic epidemiology. MR studies suffer bias from weak genetic instrument variables (IVs) and horizontal pleiotropy. We introduce a robust integrative framework strictly adhering with STROBE-MR guidelines to improve causality inference through MR studies. We implemented novel t-statistics-based criteria to improve the reliability of...

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Causality
Coronary Artery Disease
Genetic Pleiotropy
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39354059
DOI: 10.1038/s41598-024-73970-z
PMCID: PMC11445377

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