Article

A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropy

2023-06-02

Abstract excerpt

Mendelian randomization uses genetic variants as instrumental variables to make causal inferences on the effect of an exposure on an outcome. Due to the recent abundance of high-powered genome-wide association studies, many putative causal exposures of interest have large numbers of independent genetic variants with which they associate, each representing a potential instrument for use in a Mendelian randomization...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e616642d-9dcf-5473-a4a3-d299b383c4f1
DOI: 10.1101/2023.05.30.542988

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropyDOI 10.1101/2023.05.30.542988Read

Bayesian variable selection with a pleiotropic loss function in Mendelian randomizationSemantic proximity Read

Bayesian variable selection with a pleiotropic loss function in Mendelian randomization.Semantic proximity Read

Pleiotropy-robust Mendelian randomization.Semantic proximity Read

Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy.Semantic proximity Read

A robust penalized-regression-based method for multivariable Mendelian randomization using GWAS summary statisticsSemantic proximity Read

MRCIP: a robust Mendelian randomization method accounting for correlated and idiosyncratic pleiotropy.Semantic proximity Read

MR-LDP: a two-sample Mendelian randomization for GWAS summary statistics accounting for linkage disequilibrium and horizontal pleiotropySemantic proximity Read

Weak and pleiotropy robust sex-stratified Mendelian randomization in the one sample and two sample settings.Semantic proximity Read

Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects.Semantic proximity Read

MRBEE: A bias-corrected multivariable Mendelian randomization method.Semantic proximity Read

Mendelian randomization under the omnigenic architecture.Semantic proximity Read