Article

Bayesian variable selection with a pleiotropic loss function in Mendelian randomization

2019-04-04

Abstract excerpt

Mendelian randomization is the use of genetic variants as instruments to assess the existence of a causal relationship between a risk factor and an outcome. A Mendelian randomization analysis requires a set of genetic variants that are strongly associated with the risk factor and only associated with the outcome through their effect on the risk factor. We describe a novel variable selection algorithm for Mendelian...

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Literature Corpus work: 5ee40329-4d1b-535c-8c42-75d4202ccb8c
DOI: 10.1101/593863

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