Article

Dissecting the genetic overlap between three complex phenotypes with trivariate MiXeR

2024-02-27

Abstract excerpt

Comorbidities are an increasing global health challenge. Accumulating evidence suggests overlapping genetic architectures underlying comorbid complex human traits and disorders. The bivariate causal mixture model (MiXeR) can quantify the polygenic overlap between complex phenotypes beyond global genetic correlation. Still, the pattern of genetic overlap between three distinct phenotypes, which is important to bett...

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Identifiers and source

Literature Corpus work: 99538c5d-9b89-5a3b-ab9a-f6865192d81e
DOI: 10.1101/2024.02.23.24303236

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