Article

Bayesian mixture model for clustering rare-variant effects in human genetic studies

2021-08-05

Abstract excerpt

Rare-variant aggregate analysis from exome and whole genome sequencing data typically summarizes with a single statistic the signal for a gene or the unit that is being aggregated. However, when doing so, the effect profile within the unit may not be easily characterized across one or multiple phenotypes. Here, we present an approach we call Multiple Rarevariants and Phenotypes Mixture Model (MRPMM), which cluster...

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Literature Corpus work: 6277105c-2441-5ab3-a14f-dc8b711cde01
DOI: 10.1101/2021.08.03.454967

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