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Article

Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR.

Genome medicine - 29 Sept 2025

Shadrin Alexey A, Hindley Guy, Hagen Espen, Parker Nadine, Tesfaye Markos, Jaholkowski Piotr, Rahman Zillur, Kutrolli Gleda, Fominykh Vera, Djurovic Srdjan, Smeland Olav B, O'Connell Kevin S, van der Meer Dennis, Frei Oleksandr, Andreassen Ole A, Dale Anders M

Abstract excerpt

BACKGROUND: Multimorbidities are a global health challenge. Accumulating evidence indicates that overlapping genetic architectures underlie comorbid complex human traits and disorders. This can be quantified for a pair of phenotypes using various techniques. Still, the pattern of genetic overlap between three distinct complex phenotypes, which is important for understanding multimorbidities, has not been possible...

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PMID: 41023670
DOI: 10.1186/s13073-025-01528-3
PMCID: PMC12482798

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