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Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation.

The American journal of psychiatry - 1 Nov 2022

Hindley Guy, Frei Oleksandr, Shadrin Alexey A, Cheng Weiqiu, O'Connell Kevin S, Icick Romain, Parker Nadine, Bahrami Shahram, Karadag Naz, Roelfs Daniel, Holen Børge, Lin Aihua, Fan Chun C, Djurovic Srdjan, Dale Anders M, Smeland Olav B, Andreassen Ole A

Abstract excerpt

OBJECTIVE: Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple disorders and related traits, mirroring their overlapping clinical characteristics. However, rg may underestimate the shared genetic underpinnings of mental disorders and related traits because it does not differentiate mixtures of concordant and...

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Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mental Disorders

Multifactorial Inheritance

Polymorphism, Single Nucleotide

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PMID: 36069018
DOI: 10.1176/appi.ajp.21101051
PMCID: PMC9633354

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