Article

Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders

2025-12-17

Abstract excerpt

<h4>Summary</h4> The growing number of genomic discoveries in complex human traits has highlighted the need for advanced functional genomics tools that parse their polygenic and pleiotropic genetic architecture to provide biological insights. We present bivariate GSA-MiXeR, a novel tool that models the partitioned heritability and covariance of two traits within a genomic region of interest (ROI) and estimates th...

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Literature Corpus work: c0124ca9-f75b-53ae-880a-b6c1d5476383
DOI: 10.64898/2025.12.16.25342384

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