Computationally efficient methods for estimating phenome-wide coheritability of multi-type phenotypes using biobank data.

Abstract excerpt

Biobank data provide a rich source for studying the coheritability of multiple disease phenotypes, which can provide information on shared genetic etiology. However, the large number and heterogeneous types of phenotypes (e.g., continuous, discrete, time-to-event) pose significant statistical and computational challenges for estimating coheritability. In this work, we propose a unified modeling framework with...

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