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Article

Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset.

Biological psychiatry - 15 Sept 2025

van der Meer Dennis, Hindley Guy, Shadrin Alexey A, Smeland Olav B, Parker Nadine, Dale Anders M, Frei Oleksandr, Andreassen Ole A

Abstract excerpt

Psychiatric disorders have complex genetic architectures with substantial genetic overlap across conditions, which may partially explain their high levels of comorbidity. This presents significant challenges to research. Genome-wide association studies (GWASs) have uncovered hundreds of loci associated with single disorders, but the genetic landscape of psychiatric disorders has remained largely obscure. Moving...

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Identifiers

PMID: 39983952
DOI: 10.1016/j.biopsych.2025.02.886
PMCID: PMC13186938

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