Article

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

2024-12-05

Abstract excerpt

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Analysis (GNA), an analytic framework that applies the principles of network modelling to estimates of genetic overlap derived from genome-wide association study (GWAS) summary statistics. The result is a genomic network...

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Literature Corpus work: 7556c794-53b2-5c04-a8a3-d5c67718791e
DOI: 10.1101/2024.12.03.24318432

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