Article

Nuclear GAPDH cascade mediates stress-dependent pathological cardiac growth

2019-11-16

Abstract excerpt

Here we report that stress-induced nuclear translocation of GAPDH mediates heart hypertrophy via Brahma-Related-Gene-1 (BRG1)-associated chromatin remodelling. In response to pressure overload elicited by transverse aortic constriction, we observed nuclear translocation of GAPDH in the mouse heart. We also demonstrated a robust nuclear localization of GAPDH in cardiomyocytes from patients with dilated hypertrophic...

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Literature Corpus work: 993e6243-e4bf-5f01-a64d-9e03beb0439c
DOI: 10.1101/844902

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