Article

Targeting mutant TNNT2-induced epigenetic perturbation and pathogenic signaling in left ventricular non-compaction cardiomyopathy

2024-10-11

Abstract excerpt

<h4>Background</h4> Compound mutations of TNNT2 R 141 W/+ (encoding troponin T) and MYPN S 1296 T/+ (encoding myopalladin) are associated with familial left ventricle non-compaction cardiomyopathy (LVNC). However, it remains unclear in which would be the pathogenic mutation, the underlying mechanism, and the target therapy for LVNC. <h4>Methods</h4> Knock-in C57BL/6J mice harboring mutations in orthologous genes i...

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Literature Corpus work: 269cbab2-b967-58f0-a402-eaf7d3d3f338
DOI: 10.1101/2024.10.09.24314670

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