Article
Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype.
American journal of physiology. Heart and circulatory physiology - 1 Apr 2023
Li Yijia, Kubo Hajime, Yu Daohai, Yang Yijun, Johnson Jaslyn P, Eaton Deborah M, Berretta Remus M, Foster Michael, McKinsey Timothy A, Yu Jun, Elrod John W, Chen Xiongwen, Houser Steven R
Abstract excerpt
Heart failure (HF) with preserved ejection fraction (HFpEF) is defined as HF with an ejection fraction (EF) ≥ 50% and elevated cardiac diastolic filling pressures. The underlying causes of HFpEF are multifactorial and not well-defined. A transgenic mouse with low levels of cardiomyocyte (CM)-specific inducible Cavβ2a expression (β2a-Tg mice) showed increased cytosolic CM Ca2+, and modest levels of CM hypertrophy,...
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