Article

LncRNA Bigheart trans-activates gene expression in a feed forward mechanism that facilitates calcineurin-NFAT signaling in myocardial hypertrophy

2023-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Terminally differentiated cardiomyocytes exhibit hypertrophy as a default response to injury by translating biomechanical stress into a complex network of intracellular signaling events. The molecular intricacies how calcium-dependent signaling engage molecular circuits and epigenetic modifications to activate deleterious gene programs remain enigmatic. Here we report on the re-activation of the...

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Literature Corpus work: b038e952-6871-5cd1-8010-9316d96afea3
DOI: 10.1101/2023.12.11.571094

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LncRNA Bigheart trans-activates gene expression in a feed forward mechanism that facilitates calcineurin-NFAT signaling in myocardial hypertrophyDOI 10.1101/2023.12.11.571094Read

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