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Article

Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation.

The Journal of biological chemistry - 4 Jan 2013

Chang Chia-Wei Jenny, Lee Linda, Yu David, Dao Khanha, Bossuyt Julie, Bers Donald M

Abstract excerpt

During hemodynamic stress, catecholamines and neurohumoral stimuli may induce co-activation of G(q)-coupled receptors and β-adrenergic receptors (β-AR), leading to cardiac remodeling. Dynamic regulation of histone deacetylase 5 (HDAC5), a transcriptional repressor, is crucial during stress signaling due to its role in epigenetic control of fetal gene markers. Little is known about its regulation during acute and...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Share to Receptors, Adrenergic, beta

Source

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Identifiers

PMID: 23161540
DOI: 10.1074/jbc.M112.382358
PMCID: PMC3537013

Genes

HDAC5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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