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Article

BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.

Scientific reports - 17 May 2022

Scherba Jacob C, Halushka Marc K, Andersen Nicholas D, Maleszewski Joseph J, Landstrom Andrew P, Bursac Nenad, Glass Carolyn

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere that causes otherwise unexplained cardiac hypertrophy and is associated with sudden death. While previous studies showed the role of the epigenetic modifier Brg1 in mouse models of HCM, additional work is needed to identify its role in humans. We tested the hypothesis that BRG1 expression is increased in periods of cardiac remodeling during...

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Identifiers

PMID: 35581268
DOI: 10.1038/s41598-022-11829-x
PMCID: PMC9114001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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