Article

Nuclear CaMKII Isoforms as Regulators of Transcription: From Developmental to Pathological Persistence

2025-10-08

Abstract excerpt

Calcium/calmodulin-dependent protein kinase II (CaMKII) comprises multiple isoforms with distinct nuclear variants that exert transcriptional control in a context-dependent manner. Among them, CaMKIIδB and δ9 in the heart, and CaMKIIγ in the nervous system, have emerged as regulators of chromatin dynamics, transcription factor activity, and developmental gene programs. Nuclear localization is driven by splice-depe...

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Literature Corpus work: 465ca317-453e-54b0-8dfc-3c9d23584c94
DOI: 10.20944/preprints202510.0599.v1

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