Article
Cryo-EM reveals structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations.
Nature communications - 17 Apr 2026
Nguyen Binh An, Fernandez-Ramirez Maria Del Carmen, Bassett Parker, Singh Virender, Singh Preeti, Pękała Maja, Villalon Layla, Ahmed Yasmin, Lemoff Andrew, Evers Bret, Lopez Christian, Kluve-Beckerman Barbara, Saelices Lorena
Abstract excerpt
Hereditary apolipoprotein A-I (AApoA‑I) amyloidosis is a rare systemic disease caused by the deposition of amyloid fibrils formed by apolipoprotein A‑I in multiple organs, leading to severe clinical outcomes. With no available therapies or diagnostic tools, defining the structure of AApoA‑I fibrils is crucial to understanding disease mechanisms and guiding intervention. Here we use cryo-electron microscopy to...
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