Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway.

doi:10.1038/s41467-026-75958-x

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Article

Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway.

Nature communications - 23 Jul 2026

Bassett Parker T, Nguyen Binh A, Singh Virender, Garrett Patrick T, Moresco James J, Eddy Joshua, Afrin Shumaila, Pękała Maja, Lopez Christian, Evers Bret M, Ahmed Yasmin, Pedretti Rose, Grodin Justin L, Roth Lori R, Kaur Gurbakhash, Chung Stephen, Morgan Gareth J, Yates John R, Saelices Lorena

Abstract excerpt

Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by the misfolding and aggregation of free immunoglobulin light chains (LCs) secreted by abnormal plasma cells. The resulting amyloid fibrils deposit in multiple organs, leading to progressive dysfunction and increased morbidity and mortality. Despite recent advances, the molecular determinants of LC aggregation and their effect on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42642410
DOI: 10.1038/s41467-026-75958-x
PMCID: PMC13507080

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