Article

Genome-wide maps of enhancer regulation connect risk variants to disease genes

2020-09-03

Abstract excerpt

Genome-wide association studies have now identified tens of thousands of noncoding loci associated with human diseases and complex traits, each of which could reveal insights into biological mechanisms of disease. Many of the underlying causal variants are thought to affect enhancers, but we have lacked genome-wide maps of enhancer-gene regulation to interpret such variants. We previously developed the Activity-by...

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Literature Corpus work: 76bab7ce-e248-5b16-93fa-341f47e790ea
DOI: 10.1101/2020.09.01.278093

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