Article

Mapping inherited genetic variation with opposite effects on autoimmune disease and cancer identifies candidate drug targets associated with the anti-tumor immune response

2023-12-28

Abstract excerpt

<h4>Background</h4> Germline alleles near genes that encode certain immune checkpoints ( CTLA4 , CD200 ) are associated with autoimmune/autoinflammatory disease and cancer but in opposite directions. This motivates a systematic search for additional germline alleles which demonstrate this pattern with the aim of identifying potential cancer immunotherapeutic targets using human genetic evidence. <h4>Methods</h4> P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25ded67f-3af1-532a-8e05-2acb99f70d89
DOI: 10.1101/2023.12.23.23300491

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping inherited genetic variation with opposite effects on autoimmune disease and cancer identifies candidate drug targets associated with the anti-tumor immune responseDOI 10.1101/2023.12.23.23300491Read

Mapping Inherited Genetic Variation with Opposite Effects on Autoimmune Disease and Four Cancer Types Identifies Candidate Drug Targets Associated with the Anti-Tumor Immune ResponseSemantic proximity Read

Germline genetic contribution to the immune landscape of cancerSemantic proximity Read

Germline genetic variation and predicting immune checkpoint inhibitor induced toxicitySemantic proximity Read

Overview of Research on Germline Genetic Variation in Immune Genes and Cancer Outcomes.Semantic proximity Read

An integrative multi-omics analysis of 16 autoimmune diseases and cancer outcomes highlights immune-cell regulatory mechanisms and shared genetic architectureSemantic proximity Read

The Genetic Causal Effect of Autoimmune Diseases on pan-Cancers: Evidence from Mendelian RandomizationSemantic proximity Read

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.Semantic proximity Read

Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic componentSemantic proximity Read

Autoimmune hypothyroidism GWAS reveals independent autoimmune and thyroid-specific contributions and an inverse relation with cancer riskSemantic proximity Read

The genetics of human autoimmune disease: A perspective on progress in the field and future directions.Semantic proximity Read

The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.Semantic proximity Read

Functional Genetics to Understand the Etiology of Autoimmunity.Semantic proximity Read