Article
Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis.
Frontiers in immunology - 1 Jan 2026
Meng Fanyu, Chen Ling, Li Meng, Zhang Qingqing, Wang Peiying, Lin Ruifeng, Liu Jiani, Yuan Zhao, Chen Kexin, Li Zhaoxia, Xie Yetong, Aierken Abuduwahapu, Yalkun Furkat, Li Chulan, Ma Yuan, Chen Jianhui, Xu Ziwen, Zhong Fei
Abstract excerpt
Background: Ankylosing spondylitis (AS) is a chronic inflammatory arthropathy with heritability estimated at approximately 90%, yet the effector genes and regulatory mechanisms beyond the well-established HLA-B*27 association remain incompletely defined. Translating GWAS-identified loci into biological insight requires integration of calibrated association statistics, gene-level prioritization, fine-mapping,...
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