Article

CCAR2 Dictates tTreg Instability and iTreg-Driven Dendritic Cell Tolerance via Divergent AKT/mTOR Modulation in High-Salt Microenvironments

2025-05-06

Abstract excerpt

<title>Abstract</title> Purpose A high-salt environment serves as a pro-inflammatory milieu that induces autoimmune responses by triggering self-reactive immune activation. While thymus-derived regulatory T cells (tTregs) exhibit significantly impaired immunosuppressive function under high-salt diet (HSD) conditions, the TGF-β-induced Treg subset (iTregs) retains full stability and functional integrity in hig...

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Literature Corpus work: 98eebeeb-eb2c-543a-b148-e4ff8c877b53
DOI: 10.21203/rs.3.rs-6528083/v1

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