Article

NCoR1 and SMRT Fine-Tune Inflammatory Versus Tolerogenic Balance in Dendritic Cells By Differentially Regulating STAT3 Signaling

2022-01-11

Abstract excerpt

<title>Abstract</title> Dendritic cell (DC) fine-tunes inflammatory versus tolerogenic responses to protect from immune-pathology. However, the role of co-regulators in maintaining this balance is unexplored. NCoR1-mediated repression of DC immune-tolerance has been recently reported. Here we found that depletion of NCoR1 paralog SMRT (NCoR2) enhanced cDC1 activation and expression of IL-6, IL-12 and IL-23 whi...

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Literature Corpus work: 3c12a967-72ae-5c20-b57e-2ab9b865f15a
DOI: 10.21203/rs.3.rs-1204554/v1

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