Article

PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3 <sup>+</sup> Regulatory T cells

2018-08-02

Abstract excerpt

Foxp3 + regulatory T cells (Tregs) are the central component of peripheral immune tolerance. While dysregulation of the Treg cytokine signature has been observed in autoimmune diseases such as multiple sclerosis (MS) and type 1 diabetes, the regulatory mechanisms balancing pro- and anti-inflammatory cytokine production are not known. Here, we identify imbalance between IFNγ and IL-10 as a shared Treg signature, p...

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Literature Corpus work: 8538ba3e-f8d7-5a60-89b1-361742f97ca2
DOI: 10.1101/379453

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