Article

atRA mitigates high salt-driven EAE by stabilizing Treg cell mediated the inhibition of IL- 23R and the repairment of compromised endogenous RA signaling

2024-04-03

Abstract excerpt

<title>Abstract</title> High salt diet (HSD) is implicated in numerous disorders. HSD boosts Th17 development, compromises the immunosuppressive function of thymic Treg cells leading to the exacerbation of EAE. However, little is known regarding the harness of excessive proinflammatory responses evoked by HSD. Here we show that atRA, a key vitamin A metabolite with multifaceted immunoregulatory properties has...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4b65f1b-57e7-5e93-b407-833dca19bc5b
DOI: 10.21203/rs.3.rs-4186387/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

atRA mitigates high salt-driven EAE by stabilizing Treg cell mediated the inhibition of IL- 23R and the repairment of compromised endogenous RA signalingDOI 10.21203/rs.3.rs-4186387/v1Read

CCAR2 Dictates tTreg Instability and iTreg-Driven Dendritic Cell Tolerance via Divergent AKT/mTOR Modulation in High-Salt MicroenvironmentsSemantic proximity Read

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.Semantic proximity Read

Repeated immunization with ATRA-containing liposomal adjuvant transdifferentiates Th17 cells to a Tr1-like phenotype.Semantic proximity Read

Bile Acid Scaffold Engineering Reveals an Androstane-Triol Derivative as a Potent Immunomodulator with Therapeutic Efficacy in EAESemantic proximity Read

Retinoic Acid: A New Old Friend of IL-17A in the Immune Pathogeny of Liver FibrosisSemantic proximity Read

Dendritic cell-specific SMAD3, downstream of JAK2, contributes to inflammation and salt-sensitivity of blood pressureSemantic proximity Read

24-Nor-ursodeoxycholic acid counteracts T H 17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating T H 17 cellsSemantic proximity Read

TAGAP activates Th17 cell differentiation by promoting RhoA and NLRP3 to accelerate rheumatoid arthritis developmentSemantic proximity Read

miR-141 and miR-200a are involved in Th17 cell differentiation by negatively regulating RARB expressionSemantic proximity Read

Retinoic Acid as a Modulator of T Cell ImmunitySemantic proximity Read

Sodium chloride is an ionic checkpoint for human Th2 cell responses and shapes the atopic skin microenvironmentSemantic proximity Read

PTGER2-β-Catenin Axis Links High Salt Environments to Autoimmunity by Balancing IFNγ and IL-10 in FoxP3 + Regulatory T cellsSemantic proximity Read