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Article

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.

Cell reports - 4 Feb 2020

Yang Yujian H, Istomine Roman, Alvarez Fernando, Al-Aubodah Tho-Alfakar, Shi Xiang Qun, Takano Tomoko, Thornton Angela M, Shevach Ethan M, Zhang Ji, Piccirillo Ciriaco A

Abstract excerpt

Regulatory T (Treg) cells integrate diverse environmental signals to modulate their function for optimal suppression. Translational regulation represents a favorable mechanism for Treg cell environmental sensing and adaptation. In this study, we carry out an unbiased screen of the Treg cell translatome and identify serum/glucocorticoid-regulated kinase 1 (SGK1), a known salt sensor in T cells, as being...

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Identifiers

PMID: 32023466
DOI: 10.1016/j.celrep.2020.01.002
PMCID: PMC11056843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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