Article

A luminal intermediate cell state maintains long-term prostate homeostasis and contributes to tumorigenesis

2023-02-27

Abstract excerpt

<h4>Summary</h4> Cellular heterogeneity poses tremendous challenges for developing cell-targeted therapies and biomarkers of clinically significant prostate cancer. The origins of this heterogeneity within normal adult and aging tissue remain unknown, leaving cellular states and transcriptional programs that allow expansions of malignant clones unidentified. To define cell states that contribute to early cancer d...

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Literature Corpus work: 98d5191a-10f7-5808-bf97-aff4a2f62023
DOI: 10.1101/2023.02.24.529762

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