Article

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

2023-05-18

Abstract excerpt

To gain insight into how ERG translocations cause prostate cancer, we performed single cell transcriptional profiling of an autochthonous mouse model at an early stage of disease initiation. Despite broad expression of ERG in all prostate epithelial cells, proliferation was enriched in a small, stem-like population with mixed-luminal basal identity (called intermediate cells). Through a series of lineage tracing a...

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Literature Corpus work: 0d3a2d33-d60c-5f7b-b548-a8543a8806d9
DOI: 10.1101/2023.05.15.540839

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