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Article

ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L

26 Aug 2025

Abstract excerpt

Abstract Despite the high prevalence of ERG transcription factor translocations in prostate cancer, the mechanism of tumorigenicity remains poorly understood. Using lineage tracing, we find the tumor-initiating activity of ERG resides in a subpopulation of murine basal cells that coexpress luminal genes (BasalLum) and not in the larger population of ERG+ luminal cells. Upon ERG activation, BasalLum cells give...

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PMID: 40858905
DOI: 10.1038/s41588-025-02289-w

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