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Distinct mesenchymal cell states mediate prostate cancer progression

8 Jan 2024

Abstract excerpt

In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular changes in tumor stroma that influence PCa progression and metastasis. Analyzing mesenchymal cells from four genetically engineered mouse models (GEMMs) and correlating these...

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PMID: 38191471
DOI: 10.1038/s41467-023-44210-1

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