Article

Cellular cartography reveals mouse prostate organization and determinants of castration resistance

2024-12-28

Abstract excerpt

Inadequate response to androgen deprivation therapy (ADT) frequently arises in prostate cancer, driven by cellular mechanisms that remain poorly understood. Here, we integrated single-cell RNA sequencing, single-cell multiomics, and spatial transcriptomics to define the transcriptional, epigenetic, and spatial basis of cell identity and castration response in the mouse prostate. Leveraging these data along with a...

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Literature Corpus work: 22eaab75-66e8-5a22-9d2a-deb3cfe177dd
DOI: 10.1101/2024.12.27.630532

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