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Article

Defining cellular population dynamics at single-cell resolution during prostate cancer progression

28 Nov 2022

Abstract excerpt

Advanced prostate malignancies are a leading cause of cancer-related deaths in men, in large part due to our incomplete understanding of cellular drivers of disease progression. We investigate prostate cancer cell dynamics at single-cell resolution from disease onset to the development of androgen independence in an in vivo murine model. We observe an expansion of a castration-resistant intermediate luminal cell...

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PMID: 36511483
DOI: 10.7554/elife.79076

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