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Cellular cartography reveals mouse prostate organization and determinants of castration resistance

25 Aug 2025

Abstract excerpt

Inadequate response to androgen deprivation therapy (ADT) frequently arises in prostate cancer, driven by cellular mechanisms that remain poorly understood. Here, we integrated single-cell RNA sequencing, single-cell multiomics, and spatial transcriptomics to define the transcriptional, epigenetic, and spatial basis of cell identity and castration response in the mouse prostate. Leveraging these data along with a...

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PMID: 40854129
DOI: 10.1073/pnas.2427116122

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