Article

Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP <sup>SAA</sup> knock-in mouse model of Alzheimer’s disease

2024-02-04

Abstract excerpt

<h4>Introduction</h4> Reduced brain energy metabolism, mTOR dysregulation, and extracellular amyloid-β oligomer (xcAβO) buildup characterize AD; how they collectively promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit N utrient-induced M itochondrial A ctivity (NiMA) in cultured neurons. We now report NiMA disruption in vivo . <h4>Methods</h4> Brain energy metabolism...

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Literature Corpus work: 98c4bf1c-d0bc-579e-882f-5f31f959c6dc
DOI: 10.1101/2024.02.02.578668

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