Article

Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metformin

2024-12-28

Abstract excerpt

<h4>Background</h4> Mitochondrial structure and function alterations are key pathological features in Alzheimer’s disease (AD) brains. The adenosine monophosphate-activated protein kinase (AMPK) and its downstream effector Unc-51 like autophagy activating kinase 1 (ULK1) represent a key node controlling mitochondria health, the alteration of which likely contribute to AD development. <h4>Methods</h4> We designed...

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Literature Corpus work: c10f2f8a-29aa-5f2e-8c7c-b8d7fad010fc
DOI: 10.1101/2024.12.28.630598

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Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metforminDOI 10.1101/2024.12.28.630598Read

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