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Article

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.

Molecular neurodegeneration - 3 Jun 2026

Nicholson LaShae, Tang Si Jie, Karra Tejaswini, Abouelatta Habiba, Strittmatter Stephen M

Abstract excerpt

BACKGROUND: Metabolic dysfunction contributes to the risk and progression of Alzheimer's disease (AD), yet the cellular mechanisms linking impaired insulin signaling and systemic metabolic stress to brain dysfunction remain incompletely defined. METHODS: We examined the impact of chronic high-fat, high-sugar (HFHS)-induced insulin resistance on metabolic parameters, spatial learning and memory, and in vivo glial...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42237401
DOI: 10.1186/s13024-026-00946-0
PMCID: PMC13459496

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