Article

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> The tumor microenvironment (TME) actively contributes to pancreatic ductal adenocarcinoma (PDAC) pathogenesis through dynamic bidirectional tumor–stroma interactions. Here, we demonstrate that homologous recombination-defective (HRD) tumor epithelium reprograms the TME in a genotype-specific manner to enhance cancer aggressiveness. Using genetically engineered mouse models, pancreatic stellate c...

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Literature Corpus work: 98af4ce4-e968-52b7-a7a2-4f1691c9dc44
DOI: 10.1101/2025.09.16.676458

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