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Targeting tumor-intrinsic TAK1 triggers anti-tumor immunity and sensitizes pancreatic cancer to checkpoint blockade

2025-10-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Targeting the Transforming Growth Factor-β (TGF-β) pathway to reverse the immunologically “cold” tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) remains clinically unsuccessful, warranting novel therapeutic strategies. <h4>Methods</h4> We developed a novel tumor-CD8 T cell co-culture to interrogate the TGF-β signaling pathways that promotes...

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Literature Corpus work
d3a3f334-4528-54be-8218-53f996c2be08
DOI
10.1101/2025.10.08.681226
Open publication

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Targeting tumor-intrinsic TAK1 triggers anti-tumor immunity and sensitizes pancreatic cancer to checkpoint blockadeDOI 10.1101/2025.10.08.681226
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