Article

Systematic Single-Cell Dissection of Cell Cycle and TGFβ-Induced State Transitions Underlying Gemcitabine Resistance in 3D Pancreatic Tumor Tissue Models

2025-11-25

Abstract excerpt

<title>Abstract</title> <p>Background: Pancreatic ductal adenocarcinoma (PDAC) is highly lethal due to late diagnosis and rapid resistance to chemotherapy (e.g. Gemcitabine, GEM) with poor outcome. We investigate resistance mechanisms in a 3D tissue model. <h4>Methods:</h4> We established a three dimensional PANC-1 model on a decellularized porcine intestinal tissue matrix, recapitulating patient-like features. N...

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Literature Corpus work: 08daf604-403c-5ece-a070-82354353dfd9
DOI: 10.21203/rs.3.rs-7825090/v1

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