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Article

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

23 Feb 2017

Abstract excerpt

Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or if subtypes of CAFs with distinct phenotypes in PDA exist. We identified a CAF subpopulation with elevated...

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PMID: 28232471
DOI: 10.1084/jem.20162024

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