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Article

Loss of ATM accelerates pancreatic cancer formation and epithelial–mesenchymal transition

29 Jul 2015

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor lesions coupled with a pronounced fibrotic reaction. ATM-targeted...

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PMID: 26220524
DOI: 10.1038/ncomms8677

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