Article

Solid tumors exploit proton-sensing GPR65 for orchestration of an immunosuppressive tumor microenvironment

2023-07-05

Abstract excerpt

<title>Abstract</title> <p>Extracellular acidification profoundly influences anti-tumor immunity but the molecular details of this immune evasion mechanism are not well understood. Here we demonstrate that tumor-associated macrophages (TAM) are capable of sensing H+ ions in a G protein-coupled receptor (GPR)65-dependent manner. This sensing induces a functional polarization of TAM towards an anti-inflammatory phe...

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Literature Corpus work: 98886e2d-1ded-5db9-a5e0-e8dddd4542b3
DOI: 10.21203/rs.3.rs-3057487/v1

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